Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 17/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528027 | 0.82 | KDM4E (0.50) | — | |
| SCHEMBL527683 | 0.81 | PARP1 (0.50) | CD38CYP3A4PARP1KCNH2 | |
| SCHEMBL3242174 | 0.75 | PARP1 (0.47) | PARP1 | |
| SCHEMBL27913538 | 0.73 | KDM4E (0.49) | CYP3A4 | |
| SCHEMBL20680339 | 0.72 | CD38 (0.59) | CD38CYP3A4PARP1KCNH2 | |
| SCHEMBL14842961 | 0.71 | SSTR4 (0.39) | PARP1 | |
| SCHEMBL6026073 | 0.71 | ALDH1A1 (0.49) | — | |
| SCHEMBL666444 | 0.71 | PARP1 (0.61) | PARP1 | |
| SCHEMBL28755091 | 0.70 | PARP1 (0.50) | CD38CYP3A4PARP1KCNH2 | |
| SCHEMBL672454 | 0.70 | CYP1A2 (0.61) | CD38PARP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10087166-B2 | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2018-10-02 | — | — | US | disclosed |
| US-20170129877-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2017-05-11 | — | — | US | disclosed |
| US-9586938-B2 | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2017-03-07 | — | — | US | disclosed |
| CN-103140484-B | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH | 2015-04-22 | — | — | CN | disclosed |
| US-20130217709-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-08-22 | — | — | US | disclosed |
| EP-2598497-A1 | CYCLIC AMINE AZAHETEROCYCLIC CARBOXAMIDES | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| CN-103140484-A | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH | 2013-06-05 | — | — | CN | disclosed |
| WO-2012016001-A1 | CYCLIC AMINE AZAHETEROCYCLIC CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217709-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MKI67, AZI2, PCNA | CD38 54/4885CYP3A4 3515/4885PARP1 84/4885 |
| US-20170129877-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MKI67, AZI2, PCNA | CD38 54/4885CYP3A4 3515/4885PARP1 84/4885 |
| US-10087166-B2 | Cyclic amine azaheterocyclic carboxamides | MKI67, AZI2, PCNA | CD38 54/4885CYP3A4 3515/4885PARP1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.