SCHEMBL5280119

SCHEMBL5280119

Cc1c(C#N)nnn1C(C)C

nearest known ligand 0.30

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.30
CYP2C19 P33261 2/20 0.30
CHEK1 O14757 1/20 0.30
ABL1 P00519 1/20 0.30
PDGFRB P09619 1/20 0.30
PDGFRA P16234 1/20 0.30
FLT1 P17948 1/20 0.30
GRK5 P34947 1/20 0.30
KDR P35968 1/20 0.30
MAP2K2 P36507 1/20 0.30
CDK8 P49336 1/20 0.30
GSK3A P49840 1/20 0.30
GSK3B P49841 1/20 0.30
PRKX P51817 1/20 0.30
NEK2 P51955 1/20 0.30
LIMK1 P53667 1/20 0.30
MAP2K1 Q02750 1/20 0.30
PRKCQ Q04759 1/20 0.30
MAP4K2 Q12851 1/20 0.30
DYRK1A Q13627 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5276801 0.79 ALDH1A1 (0.30) CYP1A2CYP2C19ALDH1A1SMN1; SMN2
SCHEMBL5280290 0.78 TOP2A (0.31)
SCHEMBL5276629 0.78 MAPT (0.30)
SCHEMBL5282651 0.78 CYP1A2 (0.33) CYP1A2CYP2C19POLB
SCHEMBL5276896 0.78 MAPT (0.30)
SCHEMBL5286521 0.75
SCHEMBL5281228 0.75
SCHEMBL5275898 0.73
SCHEMBL5278742 0.73
SCHEMBL5280800 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1859781-A2 Brightening and/or colouring agent with triazoles Henkel Kommanditgesellschaft auf Aktien (DE) 2007-11-28 EP disclosed