SCHEMBL5280419

SCHEMBL5280419

Cc1ccc(C)c(-c2ccc(Cl)cc2)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.42
GRM2 Q14416 1/20 0.42
ESRRA P11474 1/20 0.41
AGTR1 P30556 1/20 0.41
MAP4K4 O95819 1/20 0.41
CYP3A4 P08684 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
GFER P55789 1/20 0.40
KMT2A Q03164 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
MAPT P10636 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
SUCNR1 Q9BXA5 1/20 0.39
ALKBH3 Q96Q83 1/20 0.39
ALDH1A1 P00352 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10452705 0.88 NPSR1 (0.41) AHRMAP4K4ALKBH3
SCHEMBL10389844 0.87 MAP4K4 (0.47) MAP4K4CYP3A4NPC1RAB9AKMT2A
SCHEMBL13176931 0.86 MAP4K4 (0.50) AHRMAP4K4CYP3A4NPC1RAB9A
SCHEMBL30445989 0.86 ESRRA (0.46) ESRRAKMT2AHPGDALDH1A1TDP1
SCHEMBL1046094 0.86 ESRRA (0.46) ESRRANPC1RAB9AKMT2AHPGD
SCHEMBL139182 0.86 ESRRA (0.46) ESRRAKMT2AHPGDALDH1A1TDP1
SCHEMBL10827247 0.84 AHR (0.43) AHRGRM2AGTR1NPC1RAB9A
SCHEMBL14850871 0.83 KMT2A (0.46) AHRGRM2NPC1RAB9AGFER
SCHEMBL10081930 0.81 PIM1 (0.46) AHRGRM2AGTR1NPC1RAB9A
SCHEMBL7443976 0.79 CYP3A4 (0.46) AHRGRM2CYP3A4NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103980192-A Selective synthesis method of cyprosulfamide with different crystal forms TAIZHOU BAILLY CHEMICAL CO LTD 2014-08-13 CN claimed
EP-0423747-B1 Glycosyl-etoposide prodrugs, process for their preparation and their use in combination with functionalised tumour-specific enzyme conjugates BEHRINGWERKE AG (DE) 1998-07-22 EP claimed
CN-103980192-B A kind of method of selectivity synthesis different crystal forms boscalid amine TAIZHOU BAILLY CHEMICAL CO., LTD. (CN) 2016-02-17 CN disclosed
CN-103980192-A Selective synthesis method of cyprosulfamide with different crystal forms TAIZHOU BAILLY CHEMICAL CO LTD 2014-08-13 CN disclosed
EP-1313560-B1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2007-12-19 EP disclosed
EP-1313560-A4 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2005-02-09 EP disclosed
EP-1313560-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2003-05-28 EP disclosed
US-6562989-B2 Bicyclopentyl iron ligand and transition metal catalyst YALE UNIVERSITY 2003-05-13 US disclosed
US-20030008768-A1 Catalyst for aromatic C-O, C-N, and C-C bond formation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-01-09 US disclosed
WO-2002011883-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2002-02-14 WO disclosed