Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5287131 | 0.94 | L3MBTL1 (0.45) | NPSR1LMNANPY2RHDAC1HTT | |
| SCHEMBL2294510 | 0.81 | SMN1; SMN2 (0.42) | NPSR1LMNAHTTKDM4EALDH1A1 | |
| SCHEMBL2292264 | 0.81 | NPC1 (0.44) | LMNAHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL2294482 | 0.81 | NAMPT (0.48) | LMNAKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL2292578 | 0.80 | KDM4E (0.44) | NPSR1LMNANPY2RHTTKDM4E | |
| SCHEMBL2294478 | 0.80 | NPC1 (0.48) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5302265 | 0.80 | EPHX2 (0.48) | LMNANPY2RKDM4ETDP1ALDH1A1 | |
| SCHEMBL2294191 | 0.79 | NPC1 (0.38) | NPSR1LMNAGAACYP3A4CYP2D6 | |
| SCHEMBL2298594 | 0.79 | KMT2A (0.46) | LMNAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2295362 | 0.79 | SMN1; SMN2 (0.43) | LMNAHTTKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |