SCHEMBL5280558

SCHEMBL5280558

CC(=O)NC[C@H]1CN(c2cc(F)c(N3CC(=O)C3)c(F)c2)C(=O)O1

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.61
MAOB P27338 3/20 0.61
PTGS1 P23219 2/20 0.61
SDHA P31040 2/20 0.61
LMNA P02545 1/20 0.61
CALML3 P27482 1/20 0.61
F10 P00742 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10152009 0.91 MAOA (0.59) MAOAMAOBPTGS1SDHALMNA
SCHEMBL5320616 0.89 MAOA (0.57) MAOAMAOBPTGS1SDHALMNA
SCHEMBL3207960 0.89 MAOA (0.62) MAOAMAOBPTGS1SDHALMNA
SCHEMBL3207948 0.89 MAOA (0.62) MAOAMAOBPTGS1SDHALMNA
SCHEMBL5325395 0.89 MAOA (0.49) MAOAMAOBPTGS1SDHALMNA
SCHEMBL5320218 0.89 MAOA (0.61) MAOAMAOBPTGS1SDHALMNA
SCHEMBL5292531 0.89 MAOA (0.61) MAOAMAOBPTGS1SDHALMNA
SCHEMBL6487720 0.88 MAOA (0.60) MAOAMAOBPTGS1SDHALMNA
SCHEMBL6233737 0.88 MAOA (0.60) MAOAMAOBPTGS1SDHALMNA
SCHEMBL5328079 0.87 MAOA (0.59) MAOAMAOBPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007004049-A1 OXAZOLIDINONES CONTAINING AZETIDINE AS ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2007-01-11 WO claimed
WO-2007004049-A1 OXAZOLIDINONES CONTAINING AZETIDINE AS ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY LLC (US) 2007-01-11 WO disclosed