Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | CDK8 | P49336 | 3/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353678 | 0.88 | PDE3B (0.63) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL11123220 | 0.80 | PDE3B (0.53) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL11474002 | 0.80 | PDE3B (0.56) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL2844945 | 0.80 | PDE3B (0.56) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL11396639 | 0.80 | HPGD (0.60) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL11632009 | 0.80 | PDE3B (0.56) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL934680 | 0.80 | PDE3B (0.56) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL8481283 | 0.80 | PDGFRB (0.59) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL8898020 | 0.80 | HPGD (0.64) | PDE3BPDE3AHRH3PDGFRBCDK8 | |
| SCHEMBL11401082 | 0.79 | PDGFRB (0.57) | PDE3BPDE3AHRH3PDGFRBCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008144-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |