Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11396639 | 0.96 | HPGD (0.60) | HPGDPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10353678 | 0.90 | PDE3B (0.63) | HPGDPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL11396641 | 0.86 | HPGD (0.57) | HPGDPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL2474844 | 0.82 | HPGD (0.70) | HPGDPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL11632009 | 0.82 | PDE3B (0.56) | HPGDPDE3BPDE3AALDH1A1MET | |
| SCHEMBL2844945 | 0.82 | PDE3B (0.56) | HPGDPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL934680 | 0.82 | PDE3B (0.56) | HPGDPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL8481283 | 0.82 | PDGFRB (0.59) | HPGDPDE3BPDE3ATP53MET | |
| SCHEMBL11474002 | 0.82 | PDE3B (0.56) | HPGDPDE3BPDE3AALDH1A1MET | |
| SCHEMBL11634857 | 0.82 | DCUN1D1 (0.48) | HPGDPDE3BPDE3AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656631-A | LIGANDS OF CHOLINERGIC RECEPTORS; TREATMENT OF MEMORY AND NERVOUS SYSTEM DISORDERS | SANOFI (FR) | 1997-08-12 | — | — | US | disclosed |
| US-5461053-A | Cognition activator | SANOFI (FR) | 1995-10-24 | — | — | US | disclosed |
| US-5081119-A | Muscarinic antagonists, dememtia, Alzheimer,s | SANOFI (FR) | 1992-01-14 | — | — | US | disclosed |
| US-4404203-A | AND 6-PHENYL-4,5-DIHYDRO-3/2H/-PYRIDAZINONES | WARNER-LAMBERT COMPANY (US) | 1983-09-13 | — | — | US | disclosed |
| US-4397854-A | INCREASE IN MYOCARDIAL CONTRACTILITY | WARNER-LAMBERT COMPANY (US) | 1983-08-09 | — | — | US | disclosed |
| US-4092311-A | Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates | AMERICAN CYANAMID COMPANY (US) | 1978-05-30 | — | — | US | disclosed |