Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | GRK3 | P35626 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 14/20 | 0.47 |
| ▸ | CA2 | P00918 | 14/20 | 0.47 |
| ▸ | CA9 | Q16790 | 10/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14496316 | 0.69 | GRK2 (1.00) | GRK2GRK5GRK3 | |
| SCHEMBL6685995 | 0.68 | MAPT (0.77) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL359383 | 0.68 | CA1 (0.73) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL27747721 | 0.68 | CA1 (0.76) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL396033 | 0.68 | CA1 (0.61) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL18955311 | 0.67 | CA1 (0.64) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL7495027 | 0.66 | CA1 (0.69) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL14372330 | 0.66 | MEN1 (0.76) | MAPTCA1CA2CA9MEN1 | |
| SCHEMBL24325833 | 0.66 | CA1 (0.75) | MAPTCA1CA2CA9CA12 | |
| SCHEMBL2338175 | 0.66 | CA1 (0.63) | MAPTCA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |