Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL492263 | 0.94 | MEN1 (0.71) | MAOAMAOBPOLBMAPTMEN1 | |
| SCHEMBL491546 | 0.94 | MEN1 (0.71) | MEN1LMNAHTTKMT2AHRH3 | |
| SCHEMBL10200144 | 0.94 | MEN1 (0.71) | MEN1LMNAHTTKMT2AHRH3 | |
| SCHEMBL7392197 | 0.92 | POLB (0.74) | MAOAMAOBPOLBMAPTMEN1 | |
| SCHEMBL5857286 | 0.92 | MEN1 (0.69) | MEN1LMNAHTTKMT2AHRH3 | |
| SCHEMBL12835095 | 0.92 | HRH3 (0.73) | MEN1LMNAHTTKMT2AHRH3 | |
| SCHEMBL13246342 | 0.92 | HRH3 (0.71) | MEN1LMNAHTTKMT2AHRH3 | |
| Hydrochloric Acid SCHEMBL7403383 | 0.91 | POLB (0.72) | MAOAMAOBPOLBMAPTMEN1 | |
| SCHEMBL13246349 | 0.91 | HRH3 (0.73) | MEN1LMNAHTTKMT2AHRH3 | |
| SCHEMBL2629440 | 0.88 | HRH3 (0.72) | MEN1KMT2AHRH3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863487-A2 | TREATMENT OF PARKINSON'S DISEASE, OBSTRUCTIVE SLEEP APNEA, DEMENTIA WITH LEWY BODIES, VASCULAR DEMENTIA WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | claimed |
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | claimed |
| WO-2006103546-A2 | TREATMENT OF PARKINSON'S DISEASE, OBSTRUCTIVE SLEEP APNEA, DEMENTIA WITH LEWY BODIES, VASCULAR DEMENTIA WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | claimed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | claimed |