Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270109 | 0.81 | CYP2C19 (0.54) | POLBCYP3A4CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL5280750 | 0.80 | NPSR1 (0.53) | POLBCYP3A4CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL8538945 | 0.74 | CYP2C19 (0.52) | POLBCYP3A4CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL5239213 | 0.74 | P2RX4 (0.44) | CYP3A4P2RX4MEN1KMT2AP2RX1 | |
| SCHEMBL7270113 | 0.73 | POLB (0.56) | POLBCYP3A4CYP2C19HDAC8 | |
| SCHEMBL7270808 | 0.73 | CYP2C19 (0.50) | POLBCYP3A4CYP2C19GLAMMP8 | |
| SCHEMBL7279514 | 0.72 | CYP2C19 (0.47) | POLBCYP3A4CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL5453524 | 0.72 | P2RX4 (0.50) | CYP3A4CYP2C19P2RX4ALDH1A1MEN1 | |
| SCHEMBL9595767 | 0.71 | POLB (0.48) | POLBCYP3A4CYP2C19GLAMMP8 | |
| SCHEMBL18711805 | 0.69 | POLB (0.65) | POLBCYP3A4CYP2C19SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |