SCHEMBL5281455

SCHEMBL5281455

CC(=O)N1CC2(CCNCC2)c2ccccc2[C@H]1C1(C)CCCCC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.44
GAA P10253 1/20 0.44
NOTUM Q6P988 4/20 0.39
TSHR P16473 1/20 0.36
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
LMNA P02545 1/20 0.33
ATM Q13315 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
CREBBP Q92793 1/20 0.31
P2RY1 P47900 1/20 0.31
CYP1A2 P05177 3/20 0.31
CYP3A4 P08684 3/20 0.31
USP2 O75604 2/20 0.31
CYP2D6 P10635 2/20 0.31
CYP2C9 P11712 1/20 0.31
ROCK2 O75116 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4116754 0.71 ACE (0.35) NOTUMTSHRP2RY1CYP1A2CYP3A4
SCHEMBL3994423 0.70 DPP9 (0.35) NOTUMTSHRKMT2AP2RY1CYP1A2
Hydrochloric Acid SCHEMBL1747690 0.70 NOTUM (0.34) SMN1; SMN2GAANOTUMTSHRALDH1A1
SCHEMBL2172112 0.70 GAA (0.36) SMN1; SMN2GAANOTUMKMT2ACYP1A2
SCHEMBL655024 0.67 NOTUM (0.80) SMN1; SMN2GAANOTUMALDH1A1HDAC1
Hydrochloric Acid SCHEMBL2257588 0.66 NOTUM (0.78) SMN1; SMN2GAANOTUMALDH1A1HDAC1
SCHEMBL7568469 0.65 NOTUM (0.50) NOTUMALDH1A1HDAC1HDAC6P2RY1
SCHEMBL240532 0.65 MCHR2 (0.44) SMN1; SMN2GAAALOX15KCNH2SIGMAR1
SCHEMBL240533 0.65 MCHR2 (0.44) SMN1; SMN2GAAALOX15KCNH2SIGMAR1
SCHEMBL5599270 0.65 NOTUM (0.33) NOTUMROCK2ROCK1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1817036-A2 MODULATORS OF MUSCARINIC RECEPTORS Vertex Pharmaceuticals Incorporated (US) 2007-08-15 EP disclosed
WO-2006058303-A2 MODULATORS OF MUSCARINIC RECEPTORS VERTEX PHARMACEUTICALS INCORPORATED (US) 2006-06-01 WO disclosed