Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3994423 | 0.81 | DPP9 (0.35) | CYP1A2CYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL4118605 | 0.80 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL4124959 | 0.80 | HSD11B1 (0.39) | P2RY1ROCK2ROCK1HSD11B1 | |
| Hydrochloric Acid SCHEMBL1747690 | 0.80 | NOTUM (0.34) | CYP1A2CYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL1222859 | 0.73 | HSD11B1 (0.51) | CYP1A2CYP2D6TSHRHSD11B1DPP9 | |
| SCHEMBL5599306 | 0.72 | USP2 (0.33) | CYP1A2CYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL5281455 | 0.71 | SMN1; SMN2 (0.44) | CYP1A2CYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL1572534 | 0.71 | NOTUM (0.63) | NOTUMP2RY1ROCK2ROCK1AKT1 | |
| SCHEMBL30232786 | 0.71 | NOTUM (0.63) | NOTUMP2RY1ROCK2ROCK1AKT1 | |
| SCHEMBL653997 | 0.69 | DPP9 (0.50) | CYP1A2CYP3A4CYP2D6NOTUMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064187-A2 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008024497-A2 | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | claimed |