Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281624 | 1.00 | HDAC1 (0.52) | HDAC1HDAC4HDAC6KDRMEF2D | |
| SCHEMBL8260503 | 0.92 | HDAC1 (0.64) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL5287405 | 0.91 | HDAC1 (0.62) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL5278245 | 0.89 | HDAC1 (0.55) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL8260908 | 0.83 | HDAC1 (0.73) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL8259289 | 0.81 | HDAC1 (0.68) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL5280487 | 0.81 | HDAC1 (0.60) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL5280493 | 0.81 | HDAC1 (0.60) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL5281051 | 0.79 | ANPEP (0.53) | HDAC1HDAC4HDAC6MEF2DEP300 | |
| SCHEMBL5281071 | 0.79 | ANPEP (0.53) | HDAC1HDAC4HDAC6MEF2DEP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | disclosed |
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | HDAC1 1/4885HDAC4 7/4885HDAC6 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.