Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.66 |
| ▸ | HTT | P42858 | 7/20 | 0.66 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.66 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.65 |
| ▸ | HPGD | P15428 | 9/20 | 0.65 |
| ▸ | MEN1 | O00255 | 8/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.65 |
| ▸ | MITF | O75030 | 3/20 | 0.65 |
| ▸ | XBP1 | P17861 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | RECQL | P46063 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281834 | 0.84 | MAPT (0.74) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5281823 | 0.83 | MAPT (0.73) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5283971 | 0.82 | MAPT (0.89) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL6391137 | 0.82 | MAPT (0.71) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL8156930 | 0.80 | MAPT (0.71) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5288929 | 0.78 | MAPT (0.78) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL5243197 | 0.77 | MAPT (1.00) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL13436799 | 0.73 | MAPT (0.70) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL14959208 | 0.73 | MAPT (0.69) | MAPTHTTAGTR1NTSR1ALDH1A1 | |
| SCHEMBL13436906 | 0.66 | MAPT (0.59) | MAPTHTTAGTR1NTSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | claimed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | NEDD4, TRAF6, XIAP | MAPT 1681/4885HTT 722/4885AGTR1 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.