SCHEMBL5281903

SCHEMBL5281903

O=C(NS(=O)(=O)C=C1CCN(C(=O)O)CC1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.37
HDAC3 O15379 2/20 0.37
HDAC8 Q9BY41 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
LMNA P02545 1/20 0.37
TP53 P04637 1/20 0.37
GAA P10253 1/20 0.36
STS P08842 1/20 0.36
TACR1 P25103 1/20 0.36
CES2 O00748 1/20 0.36
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
HIF1A Q16665 1/20 0.35
CYP3A4 P08684 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2916404 0.85 STS (0.55) STSTACR1
SCHEMBL5616886 0.78 HDAC6 (0.35) HDAC6HDAC3HDAC8L3MBTL1LMNA
SCHEMBL21723312 0.70 IDO1 (0.39) L3MBTL1LMNAHIF1ACNR1TSHR
SCHEMBL14880119 0.64 HDAC6 (0.72) HDAC6HDAC3HDAC8GAATACR1
SCHEMBL21104349 0.64 HDAC8 (0.49) HDAC6HDAC3HDAC8GAATACR1
SCHEMBL23217170 0.63 IDO1 (0.57) L3MBTL1LMNACYP3A4TSHRIDO1
SCHEMBL23149200 0.63 CES2 (0.44) CES2CYP3A4TSHR
SCHEMBL1534297 0.62 HIF1A (0.58) L3MBTL1LMNACES2HIF1ACYP3A4
SCHEMBL24747018 0.62 CA1 (0.47) HDAC6HDAC3HDAC8GAATACR1
SCHEMBL21722902 0.62 SRD5A2 (0.41) L3MBTL1LMNACES2CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1861098-A1 ANTI-INFLAMMATORY COMPOUNDS Novartis AG (CH) 2007-12-05 EP disclosed
EP-1861099-A2 COMBINATION OF A STEROID SULFATASE INHIBITOR AND AN ASCOMYCIN Novartis AG (CH) 2007-12-05 EP disclosed
WO-2006097293-A2 COMBINATION OF A STEROID SULFATASE INHIBITOR AND AN ASCOMYCIN NOVARTIS AG (CH) 2006-09-21 WO disclosed
WO-2006097292-A1 ANTI-INFLAMMATORY COMPOUNDS NOVARTIS AG (CH) 2006-09-21 WO disclosed
EP-1436253-A1 ACYLSULFONAMIDES AS INHIBITORS OF STEROID SULFATASE Novartis AG (CH) 2004-07-14 EP disclosed
WO-2003031397-A1 ACYLSULFONAMIDES AS INHIBITORS OF STEROID SULFATASE NOVARTIS AG (CH) 2003-04-17 WO disclosed