SCHEMBL5281964

SCHEMBL5281964

Cn1nc(Br)cc1-c1cc([N+](=O)[O-])ccc1OCCBr

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE5A O76074 2/20 0.44
PTGDR2 Q9Y5Y4 1/20 0.38
S1PR4 O95977 1/20 0.38
CNR2 P34972 3/20 0.38
MAPT P10636 8/20 0.37
RXFP1 Q9HBX9 1/20 0.37
SMN1; SMN2 Q16637 4/20 0.37
HPGD P15428 3/20 0.37
LMNA P02545 3/20 0.37
ALDH1A1 P00352 3/20 0.37
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
CNR1 P21554 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1165882 0.84 HTR2A (0.43) PDE5AMAPTRXFP1
SCHEMBL1167056 0.79 HTR2A (0.44) PDE5A
SCHEMBL1166552 0.76 HTR2A (0.44) PDE5AMAPTSMN1; SMN2HPGDLMNA
SCHEMBL31174878 0.73 S1PR4 (0.44) PTGDR2S1PR4MAPTSMN1; SMN2HPGD
SCHEMBL22117910 0.73 S1PR4 (0.44) PTGDR2S1PR4MAPTSMN1; SMN2HPGD
SCHEMBL14067176 0.73 PDE5A (0.53) PDE5AMAPTRXFP1CYP1A2CYP3A4
SCHEMBL1929569 0.71 MAPT (0.58) MAPTSMN1; SMN2HPGDLMNAALDH1A1
SCHEMBL6826390 0.71 MAPT (0.58) MAPTSMN1; SMN2HPGDLMNAALDH1A1
SCHEMBL29897285 0.71 MAPT (0.58) MAPTSMN1; SMN2HPGDLMNAALDH1A1
SCHEMBL5577927 0.70 CHRNB2 (0.48) PDE5AMAPTRXFP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1833799-A2 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT-2a SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2007-09-19 EP disclosed
WO-2006055734-A2 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2006-05-26 WO disclosed