Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5300027 | 0.93 | KMT2A (0.48) | MEN1KMT2AKDRNPC1HTT | |
| SCHEMBL2298655 | 0.89 | RAB9A (0.48) | NPC1HTTMAPTSMN1; SMN2RAB9A | |
| SCHEMBL2297005 | 0.89 | MAPT (0.49) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2294478 | 0.88 | NPC1 (0.48) | MEN1KMT2ANPC1HTTMAPT | |
| SCHEMBL2295492 | 0.87 | RAB9A (0.51) | MEN1KMT2ANPC1HTTMAPT | |
| SCHEMBL2295384 | 0.86 | KCNK3 (0.46) | MEN1KMT2ANPC1HTTMAPT | |
| SCHEMBL2299812 | 0.84 | NPC1 (0.45) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2299394 | 0.84 | F2 (0.44) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2292514 | 0.83 | RAB9A (0.47) | MEN1KMT2ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2298688 | 0.83 | NPC1 (0.48) | MEN1KMT2ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |