Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 16/20 | 0.47 |
| ▸ | THRB | P10828 | 16/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351674 | 0.90 | THRA (0.48) | THRATHRBCYP3A4CYP2C19CYP2C9 | |
| SCHEMBL5354531 | 0.85 | CYP3A4 (0.40) | THRATHRBCYP3A4CYP2C19CYP2C9 | |
| SCHEMBL5351673 | 0.84 | THRA (0.43) | THRATHRBCYP3A4CYP2C19 | |
| SCHEMBL5280888 | 0.83 | THRA (0.57) | THRATHRB | |
| SCHEMBL5285435 | 0.83 | THRA (0.50) | THRATHRB | |
| SCHEMBL12312830 | 0.83 | THRA (0.50) | THRATHRBCYP3A4CYP2C19CYP2C9 | |
| SCHEMBL5367327 | 0.83 | THRA (0.62) | THRATHRBCYP3A4CYP2C19 | |
| SCHEMBL5367322 | 0.83 | THRA (0.62) | THRATHRBCYP3A4CYP2C19 | |
| SCHEMBL5964570 | 0.81 | THRA (0.46) | THRATHRBCYP3A4CYP2C19 | |
| SCHEMBL5351679 | 0.80 | THRA (0.43) | THRATHRBCYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1862450-A2 | Novel compounds | KARO BIO AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| EP-1537073-B1 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KAROBIO AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| EP-1537073-A2 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004007430-A2 | BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2004-01-22 | — | — | WO | disclosed |