Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.38 |
| ▸ | GBA1 | P04062 | 3/20 | 0.33 |
| ▸ | UGCG | Q16739 | 3/20 | 0.33 |
| ▸ | GBA2 | Q9HCG7 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2684381 | 1.00 | REN (0.38) | RENGBA1UGCGGBA2TSHR | |
| SCHEMBL2682327 | 0.93 | REN (0.38) | RENGBA1UGCGGBA2TSHR | |
| SCHEMBL2682998 | 0.92 | REN (0.36) | REN | |
| SCHEMBL3906198 | 0.92 | REN (0.37) | RENRORC | |
| SCHEMBL1039229 | 0.92 | REN (0.38) | REN | |
| SCHEMBL4582330 | 0.92 | REN (0.36) | RENGBA1UGCGGBA2TSHR | |
| SCHEMBL3945248 | 0.91 | REN (0.37) | RENGBA1UGCGGBA2TSHR | |
| SCHEMBL3914348 | 0.91 | REN (0.38) | RENRORC | |
| SCHEMBL2684133 | 0.91 | REN (0.39) | RENTSHRRORC | |
| SCHEMBL5283932 | 0.91 | REN (0.39) | RENTSHRRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863763-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | Speedel Experimenta AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103275-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |