SCHEMBL5282738

SCHEMBL5282738

CCN(CC)S(=O)(=O)c1cccs1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.61
SMN1; SMN2 Q16637 3/20 0.56
HPGD P15428 2/20 0.56
HSD17B10 Q99714 1/20 0.51
MAPT P10636 1/20 0.50
PKM P14618 1/20 0.48
GAA P10253 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
LMNA P02545 2/20 0.47
TSHR P16473 2/20 0.47
TDP1 Q9NUW8 1/20 0.47
MEN1 O00255 1/20 0.46
POLB P06746 1/20 0.46
KMT2A Q03164 1/20 0.46
HTT P42858 1/20 0.46
NPC1 O15118 1/20 0.44
KDM4E B2RXH2 1/20 0.44
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12077803 0.83 ALDH1A1 (0.68) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL8281172 0.81 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL28623420 0.80 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL28623421 0.80 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL13272627 0.79 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL7885963 0.78 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL498673 0.77 KDM4E (0.56) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL13251318 0.77 ALDH1A1 (0.44) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT
SCHEMBL9596976 0.77 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2HPGDMAPTPKM
SCHEMBL26483276 0.77 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2HPGDHSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1694659-B1 THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS SCHERING CORP (US) 2008-08-27 EP disclosed
EP-1778679-A1 PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS GLAXO GROUP LIMITED (GB) 2007-05-02 EP disclosed
WO-2006010629-A1 PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS GLAXO GROUP LIMITED (GB) 2006-02-02 WO disclosed
EP-0322164-B1 ETHANOLAMINE DERIVATIVES GLAXO GROUP LIMITED (GB) 1993-09-22 EP disclosed
US-5039697-A Adrenergic stimulants, bronchodilators GLAXO GROUP LIMITED (GB) 1991-08-13 US disclosed
US-5032609-A Ethanolamine derivatives GLAXO GROUP LIMITED (GB) 1991-07-16 US disclosed
US-5002966-A Adrenergic Stimulants GLAXO GROUP LIMITED (GB) 1991-03-26 US disclosed
EP-0322164-A2 Ethanolamine derivatives GLAXO GROUP LIMITED (GB) 1989-06-28 EP disclosed