Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17697649 | 0.90 | BACE1 (0.49) | L3MBTL1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17720733 | 0.87 | L3MBTL1 (0.50) | L3MBTL1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL180120 | 0.85 | SMN1; SMN2 (0.47) | L3MBTL1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL9378330 | 0.84 | HPGD (0.46) | FGFR1FGFR2FGFR4FGFR3KDM4E | |
| SCHEMBL6676838 | 0.83 | BACE1 (0.45) | SMN1; SMN2KMT2AMEN1MAPTRAB9A | |
| SCHEMBL25257372 | 0.82 | L3MBTL1 (0.55) | L3MBTL1SMN1; SMN2KDM4EHPGDHSD17B10 | |
| SCHEMBL17697668 | 0.81 | L3MBTL1 (0.43) | L3MBTL1SMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL17720768 | 0.79 | SMN1; SMN2 (0.47) | L3MBTL1FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17703419 | 0.79 | L3MBTL1 (0.46) | L3MBTL1SMN1; SMN2KDM4EHPGDHSD17B10 | |
| SCHEMBL17720739 | 0.79 | PDE4B (0.44) | FGFR1FGFR2FGFR4FGFR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866280-A1 | ACYL HYDRAZIDES AS KINASE INHIBITORS, IN PARTICULAR FOR SGK | Merck Patent GmbH (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105850-A1 | ACYL HYDRAZIDES AS KINASE INHIBITORS, IN PARTICULAR FOR SGK | MERCK PATENT GMBH (DE) | 2006-10-12 | — | — | WO | disclosed |