SCHEMBL5283231

SCHEMBL5283231

CC(C)=N/N=c1\sc(C)c(C)n1-c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.40
ALDH1A1 P00352 7/20 0.34
MEN1 O00255 4/20 0.34
NOTUM Q6P988 1/20 0.34
HTT P42858 3/20 0.33
MAPT P10636 3/20 0.33
GAA P10253 2/20 0.33
GSK3A P49840 2/20 0.33
GSK3B P49841 2/20 0.33
PAX8 Q06710 1/20 0.33
LMNA P02545 5/20 0.33
ALOX15 P16050 2/20 0.33
USP2 O75604 1/20 0.33
APOBEC3A P31941 1/20 0.33
HSD17B10 Q99714 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
ATM Q13315 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5279448 1.00 KMT2A (0.40) KMT2AALDH1A1MEN1NOTUMHTT
SCHEMBL5283318 0.84 KMT2A (0.40) KMT2AALDH1A1MEN1HTTMAPT
SCHEMBL5279506 0.84 KMT2A (0.40) KMT2AALDH1A1MEN1HTTMAPT
SCHEMBL4619804 0.77 KMT2A (0.54) KMT2AALDH1A1MEN1NOTUMHTT
SCHEMBL4619801 0.77 KMT2A (0.54) KMT2AALDH1A1MEN1NOTUMHTT
SCHEMBL5280716 0.75 CYP1A2 (0.50) KMT2AALDH1A1MEN1NOTUMHTT
SCHEMBL5280714 0.75 CYP1A2 (0.50) KMT2AALDH1A1MEN1NOTUMHTT
SCHEMBL5282886 0.75 CYP2C9 (0.37) KMT2AALDH1A1MEN1HTTMAPT
SCHEMBL5282968 0.75 TSHR (0.44) KMT2AALDH1A1NOTUMGSK3AGSK3B
SCHEMBL5282965 0.75 TSHR (0.44) KMT2AALDH1A1NOTUMGSK3AGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599178-B1 MEANS AND METHOD FOR DYEING KERATIN FIBRES WELLA AG (DE) 2007-12-19 EP claimed
US-7294151-B2 Means and method for dyeing keratin fibres WELLA AG (DE) 2007-11-13 US claimed
US-20060070190-A1 Means and method for dyeing keratin fibres KOYO SEIKO CO., LTD. (JP) 2006-04-06 US claimed
EP-1599178-B1 MEANS AND METHOD FOR DYEING KERATIN FIBRES WELLA AG (DE) 2007-12-19 EP disclosed
US-7294151-B2 Means and method for dyeing keratin fibres WELLA AG (DE) 2007-11-13 US disclosed
US-20060070190-A1 Means and method for dyeing keratin fibres KOYO SEIKO CO., LTD. (JP) 2006-04-06 US disclosed
EP-1599178-A1 MEANS AND METHOD FOR DYEING KERATIN FIBRES Wella Aktiengesellschaft (DE) 2005-11-30 EP disclosed
WO-2004078151-A1 MEANS AND METHOD FOR DYEING KERATIN FIBRES WELLA AKTIENGESELLSCHAFT (DE) 2004-09-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060070190-A1 Means and method for dyeing keratin fibres KRT18, KLK5, KIT KMT2A 1273/4885ALDH1A1 454/4885MEN1 3322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.