Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | MDH2 | P40926 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3088394 | 0.95 | PARP1 (0.48) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL3247853 | 0.86 | PARP1 (0.49) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL4562814 | 0.86 | PARP1 (0.45) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL50237 | 0.84 | PARP1 (0.50) | PARP1KIF11GSK3BALDH1A1SMN1; SMN2 | |
| SCHEMBL3361180 | 0.83 | PARP1 (0.44) | PARP1GSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL1173615 | 0.83 | KIF11 (0.51) | PARP1KIF11GSK3BALDH1A1SMN1; SMN2 | |
| SCHEMBL393420 | 0.81 | PARP1 (0.52) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL3981796 | 0.81 | PARP1 (0.36) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL4825608 | 0.81 | PARP1 (0.43) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL393756 | 0.81 | PARP1 (0.51) | PARP1KIF11GSK3BCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807403-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006046030-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-05-04 | — | — | WO | disclosed |