Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.42 |
| ▸ | NPC1 | O15118 | 9/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2296670 | 0.90 | NR1I2 (0.47) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2296252 | 0.90 | NR1I2 (0.47) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5299923 | 0.86 | NR1I2 (0.44) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5298326 | 0.85 | RAB9A (0.47) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5301051 | 0.83 | AURKA (0.47) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5300999 | 0.83 | SMN1; SMN2 (0.50) | RAB9ANPC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL5301184 | 0.83 | RAB9A (0.44) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5294171 | 0.83 | RAB9A (0.46) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5295207 | 0.83 | FNTA (0.45) | NR1I2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2296379 | 0.83 | NPC1 (0.46) | NR1I2RAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |