Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5282254 | 0.90 | MAPK14 (0.58) | MAPK14NPC1RAB9A | |
| SCHEMBL5291340 | 0.87 | MAPK14 (0.56) | MAPK14NPC1RAB9AMAPK13MAPK12 | |
| SCHEMBL3055917 | 0.77 | NPC1 (0.47) | MAPK14NPC1RAB9AMAPK13MAPK12 | |
| SCHEMBL15712894 | 0.76 | CYP11B2 (0.48) | MAPK14NPC1RAB9A | |
| SCHEMBL5285135 | 0.75 | MAPK1 (0.50) | MAPK14NPC1RAB9AMAPK13MAPK12 | |
| SCHEMBL24003963 | 0.74 | MAPK14 (0.52) | MAPK14NPC1RAB9A | |
| SCHEMBL3042141 | 0.73 | MAPK14 (0.48) | MAPK14NPC1RAB9A | |
| SCHEMBL25822372 | 0.72 | MAPK14 (0.46) | MAPK14 | |
| SCHEMBL15712826 | 0.72 | CYP11B2 (0.45) | MAPK14NPC1RAB9A | |
| SCHEMBL24004079 | 0.72 | MAPK14 (0.43) | MAPK14NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | claimed |
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |