Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.46 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2298363 | 0.93 | ANO1 (0.46) | ANO1HRH3MAPTALDH1A1MEN1 | |
| SCHEMBL2299363 | 0.92 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL2292791 | 0.90 | MAPT (0.54) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL2293659 | 0.86 | HTR2C (0.45) | HRH3MEN1KMT2ARAB9ALMNA | |
| SCHEMBL2294694 | 0.85 | MAPT (0.47) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL12419753 | 0.84 | HRH3 (0.50) | ANO1HRH3MAPTALDH1A1MEN1 | |
| SCHEMBL2291392 | 0.83 | KMT2A (0.51) | NR1I2ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL2295280 | 0.83 | KMT2A (0.50) | NR1I2ANO1MEN1KMT2ARAB9A | |
| SCHEMBL2296265 | 0.81 | KMT2A (0.46) | NR1I2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2295562 | 0.81 | LMNA (0.48) | NR1I2MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |