Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491707 | 1.00 | KDM4E (0.62) | KDM4EALDH1A1LTA4HSIGMAR1GRIN2A | |
| SCHEMBL14591679 | 1.00 | KDM4E (0.62) | KDM4EALDH1A1LTA4HSIGMAR1GRIN2A | |
| SCHEMBL491576 | 0.98 | KDM4E (0.64) | KDM4EALDH1A1LTA4HSIGMAR1GRIN2A | |
| Oxalic Acid SCHEMBL5856307 | 0.92 | KDM4E (0.75) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| Oxalic Acid SCHEMBL5856288 | 0.91 | KDM4E (0.77) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL5281831 | 0.90 | HRH3 (0.64) | KDM4EALDH1A1LTA4HHRH3KCNH2 | |
| SCHEMBL6052619 | 0.88 | HRH3 (0.65) | KDM4EALDH1A1LTA4HHRH3KCNH2 | |
| SCHEMBL7388724 | 0.87 | KDM4E (0.59) | KDM4EALDH1A1LTA4HGRIN2AGRIN2B | |
| SCHEMBL7392098 | 0.87 | KDM4E (0.59) | KDM4EALDH1A1LTA4HGRIN2AGRIN2B | |
| SCHEMBL19273423 | 0.85 | LTA4H (0.75) | KDM4EALDH1A1LTA4HSIGMAR1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | claimed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | claimed |
| EP-1863486-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103537-A2 | TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | disclosed |