Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560363 | 0.87 | MKNK1 (0.50) | MAPTKDM4EMKNK1MKNK2RAB9A | |
| SCHEMBL17136101 | 0.85 | MKNK1 (0.43) | MAPTHTTKDM4EMKNK1MKNK2 | |
| SCHEMBL27994859 | 0.84 | KDM4E (0.52) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL30166671 | 0.84 | MAPK9 (0.44) | MAPTMKNK1MKNK2GRM2SLC9A1 | |
| SCHEMBL319270 | 0.83 | MAPT (0.49) | MAPTHTTKDM4EMKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL18694922 | 0.82 | MAPT (0.47) | MAPTHTTKDM4EMKNK1MKNK2 | |
| SCHEMBL4805739 | 0.81 | ALDH1A1 (0.46) | MAPTKDM4EMKNK1MKNK2RAB9A | |
| SCHEMBL27641163 | 0.79 | IKBKB (0.51) | MAPTHTTMKNK1MKNK2NPC1 | |
| SCHEMBL231896 | 0.79 | MKNK1 (0.56) | MAPTHTTKDM4EMKNK1MKNK2 | |
| SCHEMBL17028059 | 0.78 | MKNK1 (0.50) | MAPTKDM4EMKNK1MKNK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732616-A | Pyrrolopyridine compounds containing biaryl amide structure, preparation method and applications thereof | 江西科技师范大学 | 2016-07-06 | — | — | CN | disclosed |
| CN-105153026-A | Biaryl amide structure containing sorafenib derivative as well as preparation method and applications thereof | UNIV JIANGXI NORMAL SCI & TECH | 2015-12-16 | — | — | CN | disclosed |
| EP-1611096-A4 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO INC (US) | 2007-08-29 | — | — | EP | disclosed |
| EP-1611096-A2 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co. Inc. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004087048-A2 | BENZAMIDE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO. INC. (US) | 2004-10-14 | — | — | WO | disclosed |