Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.62 |
| ▸ | GRM5 | P41594 | 2/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL794160 | 0.80 | PARP10 (0.74) | GRM5PARP10PARP1PARP11 | |
| SCHEMBL5284500 | 0.79 | MAPK14 (0.65) | MAPK14 | |
| SCHEMBL16573735 | 0.77 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL8151102 | 0.77 | PARP10 (0.70) | GRM5PARP10PARP1PARP11 | |
| SCHEMBL5281273 | 0.75 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL2320342 | 0.74 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL2315002 | 0.73 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL24783703 | 0.73 | PARP10 (0.63) | GRM5PARP10PARP1MKNK1PARP11 | |
| SCHEMBL552293 | 0.73 | PARP10 (0.58) | GRM5PARP10PARP1MKNK1PARP11 | |
| SCHEMBL5284312 | 0.72 | MAPK14 (0.57) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |