Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.70 |
| ▸ | PARP11 | Q9NR21 | 10/20 | 0.70 |
| ▸ | TDP2 | O95551 | 1/20 | 0.62 |
| ▸ | GRM5 | P41594 | 5/20 | 0.61 |
| ▸ | PARP1 | P09874 | 2/20 | 0.60 |
| ▸ | PRF1 | P14222 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167145 | 0.86 | PARP10 (0.76) | PARP10PARP11TDP2GRM5PARP1 | |
| SCHEMBL794160 | 0.86 | PARP10 (0.74) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL8155829 | 0.85 | PARP11 (0.68) | PARP10PARP11GRM5PARP1HRH3 | |
| SCHEMBL8151110 | 0.82 | PARP10 (0.78) | PARP10PARP11GRM5PARP1HRH3 | |
| SCHEMBL18936971 | 0.79 | MAPK1 (0.60) | PARP10PARP11GRM5PARP1PRF1 | |
| SCHEMBL20091533 | 0.78 | MAPK1 (0.59) | PARP10PARP11TDP2GRM5PARP1 | |
| SCHEMBL8163095 | 0.78 | GSK3B (0.74) | PARP10PARP11GRM5PARP1PDPK1 | |
| SCHEMBL30915406 | 0.78 | TDP2 (0.59) | PARP10PARP11TDP2GRM5PARP1 | |
| SCHEMBL5286063 | 0.77 | MAPK14 (0.62) | PARP10PARP11GRM5PARP1 | |
| SCHEMBL25060612 | 0.77 | MAPK1 (0.55) | PARP10PARP11TDP2GRM5PRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008151184-A1 | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2008-12-11 | — | — | WO | disclosed |