Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | MLYCD | O95822 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13676192 | 0.87 | TRPV1 (0.62) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL13675963 | 0.87 | TRPV1 (0.62) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL13676146 | 0.87 | TRPV1 (0.62) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL13675964 | 0.87 | TRPV1 (0.62) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL13676000 | 0.87 | TRPV1 (0.62) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL13676145 | 0.86 | TRPV1 (0.60) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL13676043 | 0.85 | MAPT (0.71) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL20625313 | 0.85 | MAPT (0.71) | TRPV1NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL5278945 | 0.84 | TRPV1 (0.59) | TRPV1NR1H4MAPTHTTRAB9A | |
| SCHEMBL13676188 | 0.83 | TRPV1 (0.65) | TRPV1NR1H4HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863756-A1 | BIARYL DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| US-20060223837-A1 | Biaryl derived amide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
| WO-2006102645-A1 | BIARYL DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223837-A1 | Biaryl derived amide modulators of vanilloid VR1 receptor | TRPV1, TRPV2, CNR1 | TRPV1 1/4885NR1H4 138/4885HDAC3 992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.