Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548879 | 0.81 | MAPK14 (0.43) | MAPK14PLATMAPK13MAPK12MAPK11 | |
| SCHEMBL13223552 | 0.64 | HDAC6 (0.39) | MAPK14PLATMAPK13MAPK12MAPK11 | |
| SCHEMBL14459895 | 0.62 | MAPK14 (0.61) | MAPK14PLATMAPK13MAPK12MAPK11 | |
| SCHEMBL16751026 | 0.62 | KMT2A (0.42) | MAPK14PLATPOLBTDP1TSHR | |
| SCHEMBL13261526 | 0.62 | TSHR (0.55) | MAPK14POLBTDP1TSHRHSP90AA1 | |
| SCHEMBL13315134 | 0.62 | MEN1 (0.42) | MAPK14TSHR | |
| SCHEMBL1534401 | 0.61 | HIF1A (0.51) | POLBTSHR | |
| SCHEMBL13245894 | 0.61 | TSHR (0.47) | PLATPOLBTDP1TSHR | |
| SCHEMBL327562 | 0.61 | MAPK1 (0.51) | POLB | |
| SCHEMBL15386475 | 0.61 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828169-A2 | UREA INHIBITORS OF MAP KINASES | Locus Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006062982-A2 | UREA INHIBITORS OF MAP KINASES | LOCUS PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |