Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 14/20 | 0.42 |
| ▸ | NPC1 | O15118 | 13/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284873 | 0.93 | GAA (0.37) | RAB9ANPC1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL2295674 | 0.84 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2292725 | 0.84 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2296419 | 0.84 | NPC1 (0.49) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2296307 | 0.84 | NPC1 (0.46) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2298719 | 0.84 | NPC1 (0.41) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2294561 | 0.83 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2298695 | 0.82 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2292549 | 0.82 | GRM4 (0.48) | RAB9ANPC1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5299923 | 0.82 | NR1I2 (0.44) | RAB9ANPC1SMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |