Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.41 |
| ▸ | CDK1 | P06493 | 4/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547038 | 0.80 | FGFR1 (0.46) | FGFR1FGFR2FGFR3KDRHDAC3 | |
| SCHEMBL546253 | 0.79 | FGFR1 (0.45) | FGFR1FGFR2FGFR3KDRHDAC3 | |
| SCHEMBL8262963 | 0.77 | FGFR1 (0.51) | FGFR1FGFR2FGFR3KDRCHEK1 | |
| SCHEMBL11888560 | 0.77 | FGFR1 (0.43) | FGFR1FGFR2FGFR3KDRHDAC3 | |
| SCHEMBL12027286 | 0.77 | FGFR1 (0.45) | FGFR1FGFR2FGFR3KDRHDAC3 | |
| SCHEMBL16070539 | 0.77 | FGFR1 (0.87) | FGFR1FGFR2FGFR3KDRJAK2 | |
| SCHEMBL30061324 | 0.76 | SMN1; SMN2 (0.44) | FGFR1FGFR2FGFR3KDRHDAC3 | |
| SCHEMBL545872 | 0.76 | SMN1; SMN2 (0.44) | FGFR1FGFR2FGFR3KDRHDAC3 | |
| SCHEMBL11037651 | 0.75 | PARP1 (0.52) | FGFR1FGFR2FGFR3KDRHDAC3 | |
| SCHEMBL16070771 | 0.75 | FGFR1 (0.87) | FGFR1FGFR2FGFR3KDRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833819-A1 | PYRAZOLE COMPOUNDS THAT MODULATE THE ACTIVITY OF CDK, GSK AND AURORA KINASES | Astex Therapeutics Limited (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006070195-A1 | PYRAZOLE COMPOUNDS THAT MODULATE THE ACTIVITY OF CDK, GSK AND AURORA KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-06 | — | — | WO | disclosed |