Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15918086 | 0.86 | PIK3CD (0.46) | HCRTR1HCRTR2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL9193063 | 0.85 | SPR (0.67) | SPRMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL2140056 | 0.83 | SPR (0.65) | SPRHPGDALDH1A1LMNAL3MBTL1 | |
| SCHEMBL11204339 | 0.80 | HTT (0.50) | SPRMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7455826 | 0.80 | PIM1 (0.52) | SPRMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7522157 | 0.79 | PIM1 (0.54) | SPRMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7455823 | 0.78 | PARP1 (0.45) | SPRMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7452732 | 0.77 | PIM1 (0.49) | SPRKMT2AHPGDALDH1A1LMNA | |
| SCHEMBL7522153 | 0.76 | NPC1 (0.46) | SPRMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL7452728 | 0.74 | PARP1 (0.45) | SPRMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598481-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015723-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |