Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11144982 | 0.79 | HRH3 (0.54) | HRH3MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3089686 | 0.79 | HRH3 (0.54) | HRH3KCNH2 | |
| SCHEMBL11397967 | 0.79 | HRH3 (0.54) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1372655 | 0.79 | HRH3 (0.54) | HRH3KCNH2 | |
| SCHEMBL5677056 | 0.79 | KEAP1 (0.56) | HRH3MAPTRAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL11142730 | 0.78 | KMT2A (0.53) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| Cyanide SCHEMBL22130096 | 0.77 | HRH3 (0.44) | HRH3MEN1KMT2ATP53MAPT | |
| SCHEMBL11405317 | 0.77 | HRH3 (0.52) | HRH3MEN1KMT2AMAPTKDM4E | |
| SCHEMBL11391433 | 0.77 | HRH3 (0.52) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11395117 | 0.77 | HRH3 (0.52) | HRH3MEN1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008144-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007008145-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |