Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043430 | 0.79 | — | — | |
| SCHEMBL4049896 | 0.73 | CXCR2 (0.39) | STK17AALDH1A1CDC7PLK4DYRK3 | |
| SCHEMBL4043422 | 0.73 | CA14 (0.32) | STK17ACDC7PLK4DYRK3JAK2 | |
| SCHEMBL8730869 | 0.66 | CDC7 (0.37) | STK17AALDH1A1GLACDC7PLK4 | |
| SCHEMBL20884449 | 0.64 | IDO1 (0.46) | DRD2STK17ASTK17BMALT1ALDH1A1 | |
| SCHEMBL8735080 | 0.63 | CDC7 (0.37) | STK17AALDH1A1GLACDC7PLK4 | |
| SCHEMBL22645632 | 0.62 | SUV39H2 (0.41) | DRD2STK17ASTK17BMALT1BCHE | |
| SCHEMBL27540073 | 0.62 | PAOX (0.39) | ALDH1A1HSD17B10 | |
| SCHEMBL988485 | 0.62 | MALT1 (0.57) | DRD2STK17ASTK17BMALT1HPGD | |
| SCHEMBL30597277 | 0.62 | MALT1 (0.57) | DRD2STK17ASTK17BMALT1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846410-A2 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | Bristol-Myers Squibb Company (US) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006086464-A2 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |