Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.35 |
| ▸ | PLK4 | O00444 | 3/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.35 |
| ▸ | INSR | P06213 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | PRKACA | P17612 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5288536 | 0.73 | DRD2 (0.32) | RPS6KB1CDC7PLK4DYRK3ROCK2 | |
| SCHEMBL25409666 | 0.71 | MEN1 (0.50) | TDP1KDM4E | |
| SCHEMBL8730869 | 0.71 | CDC7 (0.37) | CXCR2LIN28ACXCR1CD38KCNH2 | |
| SCHEMBL16585537 | 0.70 | HTT (0.49) | KDM4EALDH1A1LMNA | |
| SCHEMBL8735208 | 0.69 | CDC7 (0.38) | CXCR2LIN28ACXCR1CD38KCNH2 | |
| SCHEMBL11889090 | 0.68 | CA12 (0.51) | GSK3BCYP3A4TDP1KDM4EALDH1A1 | |
| SCHEMBL8735080 | 0.68 | CDC7 (0.37) | CXCR2LIN28ACXCR1CLCN2RPS6KB1 | |
| SCHEMBL8857062 | 0.66 | ALDH1A1 (0.50) | CXCR2LIN28ACXCR1CLCN2RPS6KB1 | |
| SCHEMBL3650105 | 0.65 | TSHR (0.48) | CLCN2CSNK2A1CYP3A4TDP1KDM4E | |
| SCHEMBL2973683 | 0.65 | HDAC3 (0.47) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846410-B1 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2009-01-21 | — | — | EP | disclosed |
| EP-1846410-A2 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | Bristol-Myers Squibb Company (US) | 2007-10-24 | — | — | EP | disclosed |
| US-7238702-B2 | Dihydroquinazolinones as 5HT modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-03 | — | — | US | disclosed |
| WO-2006086464-A2 | DIHYDROQUINAZOLINONES AS 5HT MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |
| US-20060178386-A1 | Dihydroquinazolinones as 5HT modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178386-A1 | Dihydroquinazolinones as 5HT modulators | HTR3B, HTR2C, HTR2B | CXCR2 2040/4885LIN28A 3750/4885CXCR1 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.