Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 7/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28055433 | 1.00 | ALDH1A1 (0.51) | ALDH1A1CNR1CES2CES1HDAC4 | |
| SCHEMBL3240856 | 0.82 | ALDH1A1 (0.53) | ALDH1A1CNR1CES2CES1MEN1 | |
| SCHEMBL3235781 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MEN1HPGDKMT2AL3MBTL1 | |
| SCHEMBL4851931 | 0.80 | ALDH1A1 (0.51) | ALDH1A1CNR1MEN1HPGDKMT2A | |
| SCHEMBL17466750 | 0.80 | CNR1 (0.48) | CNR1CES2CES1HDAC4HDAC7 | |
| SCHEMBL23549441 | 0.80 | ALDH1A1 (0.65) | ALDH1A1CES2CES1MEN1HPGD | |
| SCHEMBL28055444 | 0.80 | ALDH1A1 (0.51) | ALDH1A1CNR1MEN1HPGDKMT2A | |
| SCHEMBL24012849 | 0.80 | ALDH1A1 (0.51) | ALDH1A1MEN1HPGDKMT2AL3MBTL1 | |
| SCHEMBL28055389 | 0.80 | ALDH1A1 (0.65) | ALDH1A1CES2CES1MEN1HPGD | |
| SCHEMBL28055460 | 0.80 | ALDH1A1 (0.51) | ALDH1A1MEN1HPGDKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10087166-B2 | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2018-10-02 | — | — | US | disclosed |
| US-20170129877-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2017-05-11 | — | — | US | disclosed |
| US-9586938-B2 | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH (DE) | 2017-03-07 | — | — | US | disclosed |
| CN-105481715-A | Camphor Schiff base, and preparation method and application thereof | UNIV SHAANXI NORMAL | 2016-04-13 | — | — | CN | disclosed |
| CN-103140484-B | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH | 2015-04-22 | — | — | CN | disclosed |
| US-20130217709-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MERCK PATENT GMBH (DE) | 2013-08-22 | — | — | US | disclosed |
| EP-2598497-A1 | CYCLIC AMINE AZAHETEROCYCLIC CARBOXAMIDES | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| CN-103140484-A | Cyclic amine azaheterocyclic carboxamides | MERCK PATENT GMBH | 2013-06-05 | — | — | CN | disclosed |
| WO-2012016001-A1 | CYCLIC AMINE AZAHETEROCYCLIC CARBOXAMIDES | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217709-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MKI67, AZI2, PCNA | ALDH1A1 673/4885CNR1 1078/4885CES2 1816/4885 |
| US-20170129877-A1 | Cyclic Amine Azaheterocyclic Carboxamides | MKI67, AZI2, PCNA | ALDH1A1 673/4885CNR1 1078/4885CES2 1816/4885 |
| US-10087166-B2 | Cyclic amine azaheterocyclic carboxamides | MKI67, AZI2, PCNA | ALDH1A1 673/4885CNR1 1078/4885CES2 1816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.