Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449075 | 0.80 | MCL1 (0.46) | SNCAKDM4ETDP1LMNAPOLB | |
| SCHEMBL5289351 | 0.78 | SNCA (0.41) | SNCAHIF1AHSD17B10KDM4ETSHR | |
| SCHEMBL3436878 | 0.67 | MCL1 (0.61) | ERCC1ERCC4 | |
| SCHEMBL1465493 | 0.65 | CA1 (0.56) | SNCAHIF1AHSD17B10KDM4ETSHR | |
| SCHEMBL108110 | 0.64 | CA1 (0.61) | SNCAHIF1AHSD17B10KDM4ETSHR | |
| SCHEMBL13799026 | 0.63 | KDM4E (0.60) | SNCAHIF1AHSD17B10KDM4ETSHR | |
| SCHEMBL6213492 | 0.63 | KDM4E (0.50) | HIF1AHSD17B10KDM4ETDP1RGS12 | |
| SCHEMBL31387692 | 0.63 | KDM4E (0.50) | HIF1AHSD17B10KDM4ETDP1RGS12 | |
| SCHEMBL30323320 | 0.63 | IGF1R (0.56) | HIF1AHSD17B10KDM4ETSHRNFKB1 | |
| SCHEMBL29929036 | 0.63 | XDH (0.65) | SNCAHIF1AHSD17B10KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007006143-A1 | COMPOSITIONS AND METHODS FOR DETECTING TRANSFORMED CELLS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-01-18 | — | — | WO | disclosed |
| US-20050014690-A1 | Styryl acrylonitrile compounds and their use to promote myelopoiesis | THE HOSPITAL FOR SICK CHILDREN (CA) | 2005-01-20 | — | — | US | disclosed |
| EP-1453500-A1 | STYRYL ACRYLONITRILE COMPOUNDS AND THEIR USE TO PROMOTE MYELOPOIESIS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003030895-A1 | STYRYL ACRYLONITRILE COMPOUNDS AND THEIR USE TO PROMOTE MYELOPOIESIS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014690-A1 | Styryl acrylonitrile compounds and their use to promote myelopoiesis | MCL1, MYD88, MYADM | SNCA 2641/4885HIF1A 1994/4885HSD17B10 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.