Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15191075 | 0.91 | RXFP1 (0.55) | RXFP1GAANPSR1MAPK1JAK3 | |
| SCHEMBL529843 | 0.88 | RXFP1 (0.52) | RXFP1GAANPSR1MAPK1JAK3 | |
| SCHEMBL528737 | 0.83 | RXFP1 (0.49) | RXFP1GAANPSR1MAPK1JAK3 | |
| SCHEMBL531700 | 0.82 | MAPK1 (0.62) | RXFP1GAANPSR1MAPK1MEN1 | |
| SCHEMBL529799 | 0.80 | MAPK1 (0.49) | RXFP1GAANPSR1MAPK1JAK3 | |
| SCHEMBL15190721 | 0.80 | MAPK1 (0.63) | RXFP1GAANPSR1MAPK1JAK3 | |
| SCHEMBL15191195 | 0.78 | MAPK1 (0.66) | RXFP1GAANPSR1MAPK1MEN1 | |
| SCHEMBL10681872 | 0.75 | MEN1 (0.55) | RXFP1GAANPSR1MAPK1MEN1 | |
| SCHEMBL23634709 | 0.75 | MAPK1 (0.71) | RXFP1GAANPSR1MAPK1MEN1 | |
| SCHEMBL15191143 | 0.75 | MAPK1 (0.64) | RXFP1GAANPSR1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |