Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 1/20 | 0.37 |
| ▸ | ATP4B | P51164 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27358050 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KEAP1IDO1AGXTSLC6A2 | |
| SCHEMBL7197602 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KEAP1ATP4AATP4BIDO1 | |
| SCHEMBL1354441 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KEAP1ATP4AATP4BIDO1 | |
| SCHEMBL28056457 | 0.78 | IDO1 (0.40) | ALDH1A1IDO1AGXTSLC6A4PSEN1 | |
| SCHEMBL24394689 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KEAP1ATP4AATP4BIDO1 | |
| SCHEMBL28846039 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KEAP1ATP4AATP4BIDO1 | |
| SCHEMBL1548511 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KEAP1ATP4AATP4BIDO1 | |
| SCHEMBL1616245 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KEAP1ATP4AATP4BIDO1 | |
| SCHEMBL1354440 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KEAP1ATP4AATP4BIDO1 | |
| Hydrochloric Acid SCHEMBL2446106 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KEAP1ATP4AATP4BIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |