Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MASP2 | O00187 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27951533 | 1.00 | TSHR (0.40) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL27951534 | 1.00 | TSHR (0.40) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL27550708 | 0.92 | HCAR2 (0.32) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL16504472 | 0.89 | TSHR (0.44) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL18784690 | 0.83 | HCAR2 (0.55) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL18784689 | 0.83 | HCAR2 (0.55) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL7568618 | 0.80 | HCAR2 (0.42) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL4838653 | 0.80 | HCAR2 (0.42) | TSHRTP53EGLN1EGLN3HCAR2 | |
| SCHEMBL29266562 | 0.78 | LMNA (0.34) | HCAR2PPARA | |
| SCHEMBL26660918 | 0.77 | HCAR2 (0.40) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969052-B2 | Extracellular aldonolactonase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140193870-A1 | EXTRACELLULAR ALDONOLACTONASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-07-10 | — | — | US | disclosed |
| US-8703452-B2 | Extracellular aldonolactonase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-04-22 | — | — | US | disclosed |
| US-20140038245-A1 | EXTRACELLULAR ALDONOLACTONASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-02-06 | — | — | US | disclosed |
| US-8569022-B2 | Extracellular aldonolactonase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130196396-A1 | EXTRACELLULAR ALDONOLACTONASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-08-01 | — | — | US | disclosed |
| EP-2598643-A2 | EXTRACELLULAR ALDONOLACTONASE | The Regents of the University of California (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012106257-A1 | PRODUCTION OF INDUSTRIALLY RELEVANT COMPOUNDS IN PROKARYOTIC ORGANISMS | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2012-08-09 | — | — | WO | disclosed |
| WO-2012015545-A2 | EXTRACELLULAR ALDONOLACTONSE | THE REGENTS OF THE UNIERSITY OF CALIFORNIA (US) | 2012-02-02 | — | — | WO | disclosed |
| US-5026648-A | Microbial culture having catechol 1,2-oxygenase activity | CELGENE CORPORATION (US) | 1991-06-25 | — | — | US | disclosed |
| US-4731328-A | Process for the production of muconic acid | CELGENE CORPORATION (US) | 1988-03-15 | — | — | US | disclosed |
| US-4673646-A | Production of 2-hydroxymuconic semialdehyde | CELANESE CORPORATION (US) | 1987-06-16 | — | — | US | disclosed |
| US-4654303-A | Construction of novel mutant microorganisms | CELANESE CORPORATION (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0074169-B1 | MICRO-BIOLOGICAL PRODUCTION OF MUCONIC ACID | CELANESE CORPORATION (US) | 1987-01-14 | — | — | EP | disclosed |
| US-4617156-A | 2-hydroxymuconic semialdehyde bisulfite adduct | CELANESE CORPORATION (US) | 1986-10-14 | — | — | US | disclosed |
| US-4588688-A | Process for the production of muconic acid | CELANESE CORPORATION (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0138391-A1 | Construction of novel mutant micro-organisms | CELGENE CORPORATION (US) | 1985-04-24 | — | — | EP | disclosed |
| EP-0074169-A1 | Micro-biological production of muconic acid | CELANESE CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |
| EP-0071446-A2 | Construction of microorganisms | CELANESE CORPORATION (US) | 1983-02-09 | — | — | EP | disclosed |
| US-4355107-A | Production of muconic acid | CELANESE CORPORATION (US) | 1982-10-19 | — | — | US | disclosed |