Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297391 | 0.90 | ATM (0.44) | LMNAATMKMT2ANPC1RAB9A | |
| SCHEMBL2293994 | 0.88 | NPC1 (0.47) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5292979 | 0.87 | RAB9A (0.43) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2296926 | 0.85 | KMT2A (0.49) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2295353 | 0.84 | RAB9A (0.45) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2295816 | 0.84 | RAB9A (0.45) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2298509 | 0.84 | NR1H4 (0.47) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2291129 | 0.83 | ATM (0.44) | LMNAATMKMT2ANPC1RAB9A | |
| SCHEMBL2299706 | 0.83 | KMT2A (0.52) | KMT2APOLBMAPTALDH1A1TDP1 | |
| SCHEMBL2296307 | 0.83 | NPC1 (0.46) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |