Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CDKN1A | P38936 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247699 | 0.88 | CCNE2 (0.48) | SMN1; SMN2LMNABRD4KMT2APOLB | |
| SCHEMBL2853032 | 0.83 | CDKN1A (0.58) | GAACDKN1ABRD4POLBALDH1A1 | |
| SCHEMBL2836379 | 0.79 | RXFP1 (0.59) | LMNABRD4KMT2APOLBALDH1A1 | |
| SCHEMBL14493252 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2LMNAGAAMAPK1KMT2A | |
| SCHEMBL2843168 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAGAAMAPK1POLB | |
| SCHEMBL2838839 | 0.75 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAGAAMAPK1KMT2A | |
| SCHEMBL2838723 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAGAAMAPK1ALDH1A1 | |
| SCHEMBL5251798 | 0.74 | RXFP1 (0.50) | LMNABRD4KMT2APOLBALDH1A1 | |
| SCHEMBL2833833 | 0.74 | FGFR1 (0.52) | SMN1; SMN2CDKN1ABRD4KMT2APOLB | |
| SCHEMBL2837961 | 0.74 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAGAAMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662814-B2 | 4-(4-Ethylpiperazin-1-yl)-5-methyl-2-phenylthieno[2,3-d]pyrimidine-6-carbonitrile; asthma, atopic dermatitis, chronic obstructive pulmonary disease, Crohn's disease, type I and type II diabetes, lymphoid leukemia and other forms of cancer, multiple sclerosis and autoimmune diseases | LABORATORIOS ALMIRALL, S.A. (ES) | 2010-02-16 | — | — | US | disclosed |
| EP-1590352-B1 | 4-AMINOTHIENO [2,3-d] PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS | ALMIRALL LAB (ES) | 2007-06-27 | — | — | EP | disclosed |
| WO-2004065391-A1 | 4-AMINOTHIENO[2,3-d]PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS | ALMIRALL PRODESFARMA S.A. (ES) | 2004-08-05 | — | — | WO | disclosed |