Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 4/20 | 0.52 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309049 | 0.86 | FFAR1 (0.64) | HCAR2CES1FAAHFFAR1 | |
| SCHEMBL6598298 | 0.84 | HCAR2 (0.47) | HCAR2CA12CA1CA2CA9 | |
| SCHEMBL12646487 | 0.81 | HCAR2 (0.57) | HCAR2CES1FAAHFFAR1KDM4E | |
| SCHEMBL1138773 | 0.78 | HCAR2 (0.50) | HCAR2CES1FAAHFFAR1KDM4E | |
| SCHEMBL1912568 | 0.78 | FFAR1 (0.71) | CES1FFAR1HTT | |
| SCHEMBL4425355 | 0.77 | NAAA (0.68) | HCAR2ALDH1A1 | |
| SCHEMBL14268241 | 0.76 | BRS3 (0.50) | HCAR2CES1FAAHFFAR1KDM4E | |
| SCHEMBL23828889 | 0.76 | HCAR2 (0.55) | HCAR2CES1FAAHKDM4EMAPT | |
| SCHEMBL28214265 | 0.76 | CYP2A6 (0.57) | KDM4EMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL30433544 | 0.76 | ABCC4 (0.61) | HCAR2CES1FAAHFFAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |