Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 11/20 | 0.44 |
| ▸ | TP53 | P04637 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246294 | 0.91 | MCHR1 (0.56) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL13054203 | 0.81 | MAPT (0.48) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5249766 | 0.80 | MAPT (0.47) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL3753266 | 0.79 | MCHR1 (0.56) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL5246118 | 0.78 | MCHR1 (0.50) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL4641350 | 0.77 | MAPT (0.42) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL13054164 | 0.75 | HDAC6 (0.40) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL13054157 | 0.75 | MAPT (0.61) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL5248381 | 0.72 | MAPT (0.58) | MAPTTP53SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5248489 | 0.71 | HTR2C (0.55) | MCHR1MAPTTP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006066173-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-06-22 | — | — | WO | claimed |