Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.42 |
| ▸ | TP53 | P04637 | 6/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246294 | 0.86 | MCHR1 (0.56) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| SCHEMBL4641580 | 0.85 | MAPT (0.48) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| SCHEMBL3753266 | 0.82 | MCHR1 (0.56) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| SCHEMBL4642954 | 0.81 | PTGDR2 (0.39) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| SCHEMBL13054203 | 0.79 | MAPT (0.48) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| SCHEMBL13054157 | 0.79 | MAPT (0.61) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5249766 | 0.79 | MAPT (0.47) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| SCHEMBL4643568 | 0.77 | MCHR1 (0.47) | MAPTTP53MCHR1SMN1; SMN2KDM4E | |
| SCHEMBL5300628 | 0.77 | MCHR1 (0.54) | MAPTTP53THRBMCHR1SMN1; SMN2 | |
| SCHEMBL4644600 | 0.75 | MAPT (0.45) | MAPTTP53THRBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |