Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 17/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306189 | 0.88 | HCAR2 (0.53) | HCAR2SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL5062205 | 0.87 | HCAR2 (0.64) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5302935 | 0.87 | HCAR2 (0.76) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL14609869 | 0.87 | HCAR2 (0.57) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5303726 | 0.86 | GAA (0.56) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5306769 | 0.84 | HCAR2 (0.54) | HCAR2SMN1; SMN2CYP2C8CYP2C9 | |
| SCHEMBL5298682 | 0.84 | HCAR2 (0.54) | HCAR2SMN1; SMN2RAB9ACYP2C8CYP2C9 | |
| SCHEMBL5305006 | 0.83 | DHODH (0.53) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL5301194 | 0.83 | RAB9A (0.57) | HCAR2NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL5299504 | 0.83 | HCAR2 (0.53) | HCAR2ALDH1A1CYP2C8CYP2C9KDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |