Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | STK39 | Q9UEW8 | 13/20 | 0.48 |
| ▸ | PARG | Q86W56 | 3/20 | 0.48 |
| ▸ | CTSD | P07339 | 2/20 | 0.44 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5288993 | 0.93 | PTGS1 (0.49) | PTGS1TBXAS1MAPK1PTGS2MAPK14 | |
| SCHEMBL2297569 | 0.88 | TMPRSS4 (0.49) | — | |
| SCHEMBL2294406 | 0.86 | HSD17B13 (0.38) | — | |
| SCHEMBL2295598 | 0.85 | MEN1 (0.43) | PNLIP | |
| SCHEMBL2293976 | 0.84 | PTGDR2 (0.42) | — | |
| SCHEMBL2295055 | 0.84 | KDR (0.47) | — | |
| SCHEMBL2294478 | 0.83 | NPC1 (0.48) | MAPK1 | |
| SCHEMBL2296479 | 0.83 | NPC1 (0.39) | — | |
| SCHEMBL2297504 | 0.82 | FFAR1 (0.48) | MAPK1 | |
| SCHEMBL2294479 | 0.82 | FADS1 (0.46) | PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |